Spontaneous Tumor Lysis Syndrome in Childhood T cell Acute Lymphoblastic Leukemia
نویسندگان
چکیده
We report two cases that presented with unexplained acute renal failure and hyperuricemia and were subsequently diagnosed with T-cell acute lymphoblastic leukemia. The patients improved with conservative therapy without the need for dialysis. Case 1 is the youngest case of acute lymphoblastic leukemia with spontaneous tumor lysis syndrome reported to date, and Case 2 presented with spontaneous tumor lysis syndrome without hyperleukocytosis.
منابع مشابه
Identification of children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
Background and Objective: Tumor lysis syndrome (TLS) could occur before, during or after the initiation of chemotherapy in patients with cancers especially those with hematologic malignancies. This study was designed to determine the prevalence and predictors of TLS in children with Acute Lymphoblastic Lymphoma (ALL) and to develop a sensitive prediction rule to identify patients at low risk of...
متن کاملSpontaneous Fatal Tumor Lysis Syndrome in a Patient with T-Cell Lymphoblastic Lymphoma/Leukemia: Successful Treatment with Continuous Renal Replacement Therapy and Increasing-Dose Gradually Chemotherapy
Tumor Lysis Syndrome (TLS) results from massive necrosis or apoptosis of large proliferating tumors and is characterized by marked hyper uricemia, hyperkalemia, and hyper phosphatemia secondary to cell lysis and the metabolism of excessive nucleic acids. Clinically significant TLS, with end-organ compromise, occurs in approximately 5% of all patients with hematologic malignancies and in up to 2...
متن کاملRenal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia.
Spontaneous tumor lysis syndrome is a rare initial presentation of hematologic malignancy in children that typically presents with complications of electrolyte derangement, specifically hyperkalemia, hyperphosphatemia, and hyperuricemia. We report a case of a 5-year-old boy who presented to the emergency department with gross hematuria, abdominal pain, and vomiting and was ultimately diagnosed ...
متن کاملOverview the Causes of Early Deaths and Advance Supportive Care in Children with Acute Lymphoblastic Leukemia: A Systematic Review
Introduction: The objective of this study is to determine the major causes of early death in acute lymphoblastic leukemia (ALL). Methods: The following databases including PubMed, EMBASE, Science Direct and Google Scholar were searched for following terms: “acute lymphoblastic leukemia”, “early mortality”, “early death “ and “death in induction phase “. Inclusion criteria were all studies abo...
متن کاملMicroRNAs as a New Molecular Biomarker for Diagnosis and Prognosis of T-cell Acute Lymphoblastic Leukemia (T-ALL): A Systematic Review
MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This down-regulati...
متن کامل